Foureman P, Mason J M, Valencia R, Zimmering S
Department of Zoology, University of Wisconsin, Madison.
Environ Mol Mutagen. 1994;23(1):51-63. doi: 10.1002/em.2850230109.
Fifty chemicals were tested for mutagenic activity in post-meiotic and meiotic germ cells of male Drosophila melanogaster using the sex-linked recessive lethal (SLRL) assay. As in the previous studies in this series, feeding was chosen as the first route of administration. If the compound failed to induce mutations by this route, injection exposure was used. One gaseous chemical (1,3-butadiene) was tested only by inhalation. Those chemicals that were mutagenic in the sex-linked recessive lethal assay were further tested for the ability to induce reciprocal translocations. Eleven of the 50 chemicals tested were mutagenic in the SLRL assay. These included bis(2-chloroethyl) ether, 1,4-butanediol diglycidyl ether, 1-chloro-2-propanol, dimethyl methylphosphonate, dimethyl morpholinophosphoramidate, dimethyloldihydroxyethylene urea, 2,2-dimethyl vinyl chloride, hexamethylphosphoramide, isatin-5-sulfonic acid (Na salt), isopropyl glycidyl ether, and urethane. Five of these, including 1,4-butanediol diglycidyl ether, 2,2-dimethyl vinyl chloride, hexamethylphosphoramide, isopropyl glycidyl ether, and urethane, also induced reciprocal translocations.
使用性连锁隐性致死（SLRL）试验，对50种化学物质在雄性黑腹果蝇减数分裂后和减数分裂期生殖细胞中的致突变活性进行了测试。与本系列先前的研究一样，选择喂食作为第一种给药途径。如果该化合物通过此途径未能诱导突变，则采用注射暴露。一种气态化学物质（1,3 - 丁二烯）仅通过吸入进行测试。那些在性连锁隐性致死试验中具有致突变性的化学物质进一步测试其诱导相互易位的能力。所测试的50种化学物质中有11种在SLRL试验中具有致突变性。这些物质包括双（2 - 氯乙基）醚、1,4 - 丁二醇二缩水甘油醚、1 - 氯 - 2 - 丙醇、甲基膦酸二甲酯、二甲基吗啉磷酰胺、二羟甲基二羟基乙烯脲、2,2 - 二甲基氯乙烯、六甲基磷酰胺、靛红 - 5 - 磺酸（钠盐）、异丙基缩水甘油醚和尿烷。其中五种，包括1,4 - 丁二醇二缩水甘油醚、2,2 - 二甲基氯乙烯、六甲基磷酰胺、异丙基缩水甘油醚和尿烷，也诱导了相互易位。
