Misiuk-Hojło M, Ruiz-Moreno J, Thillaye B, de Kozak Y
Laboratorium Immunopatologii Oka, INSERM U 86, Paryzu.
Klin Oczna. 1993 Mar-Apr;95(3-4):101-4.
Experimental autoimmune uveoretinitis (EAU) was induced in Lewis rats by a single injection in foot pads of S-antigen in complete Freund's adjuvant. Clinically, during the 2 nd week after immunization, EAU starts by acute anterior, lately--posterior uveitis. Peptide S2, located in the N-terminal region of S-antigen, has a regulatory effect on EAU, while peptide M is a pathogenic site inducing EAU. Antibodies directed at peptide S2 were observed in rats not developing EAU while high levels of antibodies directed at S-antigen and peptide M were present in all rats.
通过在弗氏完全佐剂中于Lewis大鼠足垫单次注射S抗原诱导实验性自身免疫性葡萄膜视网膜炎（EAU）。临床上，在免疫后的第2周，EAU以急性前部、随后的后部葡萄膜炎开始。位于S抗原N端区域的肽S2对EAU具有调节作用，而肽M是诱导EAU的致病位点。在未发生EAU的大鼠中观察到针对肽S2的抗体，而在所有大鼠中均存在高水平的针对S抗原和肽M的抗体。
