Mizuno K, Clark A F, Streilein J W
Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101.
Invest Ophthalmol Vis Sci. 1989 Apr;30(4):772-4.
Uveoretinitis induced in Lewis rats by foot pad injections of retinal soluble (S) antigen is a model system used to study the immunopathogenesis of the autoimmune uveoretinitides in which delayed hypersensitivity plays a dominant role. Since down-regulation of delayed hypersensitivity can be achieved by injection of antigens into the anterior chamber of the eye, we have examined the potential of intracameral S antigen to mitigate experimental autoimmune uveitis. The results of these studies reveal that pretreatment of Lewis rats with S antigen injected into the anterior chamber markedly reduces the incidence and expression of experimental autoimmune uveitis.
通过足垫注射视网膜可溶性（S）抗原在Lewis大鼠中诱导的葡萄膜视网膜炎是一种用于研究自身免疫性葡萄膜视网膜炎免疫发病机制的模型系统，其中迟发型超敏反应起主导作用。由于通过将抗原注射到眼前房可实现迟发型超敏反应的下调，我们研究了前房内注射S抗原减轻实验性自身免疫性葡萄膜炎的潜力。这些研究结果表明，用注射到前房的S抗原对Lewis大鼠进行预处理可显著降低实验性自身免疫性葡萄膜炎的发生率和表现。
