McCann S E, Freudenheim J L, Darrow S L, Batt R E, Zielezny M A
Department of Social and Preventive Medicine, State University of New York at Buffalo.
Obstet Gynecol. 1993 Oct;82(4 Pt 1):545-9.
To examine the association of body fat distribution with risk of endometriosis in an effort to determine whether a specific somatotype is related to the disease.
We conducted a case-control study of 88 laparoscopically confirmed cases of endometriosis, identified in a specialty gynecologic practice in western New York, and 88 age-matched friend controls. Data were collected by standardized personal interview, and body measurements were taken in a standardized fashion by one interviewer. Risk of endometriosis associated with body fat distribution, as expressed by waist-to-hip and waist-to-thigh ratios, was assessed using logistic regression.
For women under 30 years of age (45 cases, 46 controls), endometriosis was inversely related to both waist-to-hip ratio (odds ratio 6.18, 95% confidence interval [CI] 2.01-19.01) and waist-to-thigh ratio (odds ratio 3.64, 95% CI 1.23-10.78). This effect was not evident among women aged 30 years and older (43 cases, 42 controls).
Our results suggest a specific somatotype with a predominance of peripheral body fat among women with endometriosis. This finding may provide information useful in both the diagnosis and understanding of the disease etiology.
研究体脂分布与子宫内膜异位症风险之间的关联，以确定特定的体型是否与该疾病相关。
我们进行了一项病例对照研究，选取了纽约西部一家专业妇科诊所通过腹腔镜确诊的88例子宫内膜异位症患者，以及88名年龄匹配的女性朋友作为对照。通过标准化的个人访谈收集数据，并由一名访谈员以标准化方式进行身体测量。使用逻辑回归评估与体脂分布相关的子宫内膜异位症风险，体脂分布用腰臀比和腰大腿比表示。
对于30岁以下的女性（45例病例，46例对照），子宫内膜异位症与腰臀比（比值比6.18，95%置信区间[CI]2.01 - 19.01）和腰大腿比（比值比3.64，95%CI 1.23 - 10.78）均呈负相关。在30岁及以上的女性中（43例病例，42例对照），这种效应并不明显。
我们的结果表明，子宫内膜异位症女性具有以周围型体脂为主的特定体型。这一发现可能为疾病的诊断和病因理解提供有用信息。
