Giralt M, Gasull T, Blánquez A, Hidalgo J
Departamento de Biología Celular y Fisiología, Facultad de Ciencias Universidad Autónoma de Barcelona, Spain.
Rev Esp Fisiol. 1993 Jun;49(2):73-8.
The effect of endotoxin on serum and lung and liver lipid peroxidation, as measured by thiobarbituric acid reactants (TBARs), as well as on lung and liver metallothionein (MT) has been studied in the rat. Endotoxin consistently increased serum and liver TBARs in a time-response manner. The increase in the serum preceded that in the liver, with peaks 3-6 h and 24 h after endotoxin administration, respectively. In contrast, lung TBARs levels did not increase regardless of the experimental approaches studied, suggesting that the rat is not a good model for the adult respiratory distress syndrome. Endotoxin increased both lung and liver MT levels in a time-response manner, although to a lesser degree in the former than in the latter tissue, indicating that this protein may have a significant role in the response of the organism to a septic insult.
通过硫代巴比妥酸反应物（TBARs）测定内毒素对大鼠血清、肺和肝脏脂质过氧化的影响，以及对肺和肝脏金属硫蛋白（MT）的影响。内毒素以时间响应方式持续增加血清和肝脏中的TBARs。血清中的增加先于肝脏中的增加，分别在内毒素给药后3 - 6小时和24小时达到峰值。相比之下，无论所研究的实验方法如何，肺TBARs水平均未增加，这表明大鼠不是成人呼吸窘迫综合征的良好模型。内毒素以时间响应方式增加肺和肝脏中的MT水平，尽管前者组织中的增加程度小于后者组织，这表明该蛋白可能在机体对脓毒症损伤的反应中起重要作用。
