Ng H T, Chang S P, Yang T S, Cho M P, Wei T C
Department of Obstetrics and Gynecology, Veterans General Hospital, National Yang-Ming Medical College, Taipei, Taiwan, ROC.
Asia Oceania J Obstet Gynaecol. 1993 Jun;19(2):115-9. doi: 10.1111/j.1447-0756.1993.tb00360.x.
Sixty-one postmenopausal women were randomized into 3 groups. Two groups of women were treated with estrogen replacement therapy (ERT) by percutaneous administration of estradiol gel at a dosage of 1.25 g and 2.5 g, respectively. The third group of women, receiving no treatment except placebo, was studied concurrently as a control group. Bone mineral density (BMD) was measured by quantitative computed tomography (QCT) in the vertebrae from T12-L3 and hormones (E1, E2, FSH, LH and testosterone) were determined by radioimmunoassay at baseline, then at 6 monthly intervals thereafter. One year of the study has been completed thus far. The results of this study indicate that: (1) loss of BMD in the control group was observed significantly only in surgical menopausal women and no significant loss of BMD was observed in women receiving ERT treatment regimens; (2) decrease of E1 in control group and increase of E1 in the treatment group were both significant. These data suggest that percutaneous ERT may be used in prevention of postmenopausal bone loss, particularly in surgical menopausal women and the increased E1 may play a beneficial role in inhibiting loss of bone mass and relieving menopausal syndrome. Different dosages of estradiol gel which did not create any significant difference between the 2 treatment groups, need a longer period of follow-up.
61名绝经后女性被随机分为3组。两组女性分别接受经皮给予雌二醇凝胶的雌激素替代疗法（ERT），剂量分别为1.25 g和2.5 g。第三组女性除安慰剂外未接受任何治疗，作为对照组同时进行研究。通过定量计算机断层扫描（QCT）测量T12 - L3椎体的骨矿物质密度（BMD），并在基线时通过放射免疫测定法测定激素（E1、E2、FSH、LH和睾酮），此后每6个月测定一次。到目前为止，该研究已完成一年。该研究结果表明：（1）仅在手术绝经女性中观察到对照组BMD显著降低，而接受ERT治疗方案的女性未观察到BMD显著降低；（2）对照组E1降低，治疗组E1升高均具有显著性。这些数据表明，经皮ERT可用于预防绝经后骨质流失，尤其是手术绝经女性，且E1升高可能在抑制骨量流失和缓解绝经综合征方面发挥有益作用。两种治疗组之间未产生任何显著差异的不同剂量雌二醇凝胶，需要更长时间的随访。
