Sentry J W, Yang M M, Kaiser K
Department of Genetics, University of Glasgow, UK.
Bioessays. 1993 Jul;15(7):491-3. doi: 10.1002/bies.950150710.
Targeting of cell ablation agents under the control of tissue-specific promoters promises to be an important tool for studies of development and function in higher organisms. Temperature-sensitive cell ablation agents, recently developed for Drosophila, extend control to temporal as well as spatial aspects of toxin expression. Here we discuss achievements to date, together with a novel form of enhancer trap technology with the potential for driving toxin expression in a large range of cell types.
在组织特异性启动子的控制下靶向细胞消融剂有望成为研究高等生物发育和功能的重要工具。最近为果蝇开发的温度敏感型细胞消融剂将毒素表达的控制扩展到了时间和空间方面。在这里，我们讨论了迄今为止所取得的成果，以及一种新型的增强子捕获技术，该技术有潜力在多种细胞类型中驱动毒素表达。
