Sentry L W, Kaiser K
Department of Genetics, University of Glasgow, UK.
Transgenic Res. 1995 May;4(3):155-62. doi: 10.1007/BF01968780.
The introduction of cloned and manipulated genetic material into the germline of an experimental organism is one of the most powerful tools of modern biology. In the case of the fruit fly, Drosophila melanogaster, there is also an unparalleled range of sophisticated genetic tools to facilitate subsequent analysis. In consequence, Drosophila remains a most favourable model organism for the dissection of gene structure and function in vivo. In this review we look at some of the achievements to date in Drosophila genome manipulation, and at what may be possible in the near future.
将克隆和操纵的遗传物质引入实验生物体的种系是现代生物学最强大的工具之一。就果蝇（黑腹果蝇）而言，还有一系列无与伦比的精密遗传工具来促进后续分析。因此，果蝇仍然是用于在体内剖析基因结构和功能的最有利的模式生物。在这篇综述中，我们将探讨果蝇基因组操作迄今为止取得的一些成就，以及在不久的将来可能实现的目标。
