Ericson K, Lilja A, Bergström M, Collins V P, Eriksson L, Ehrin E, von Holst H, Lundqvist H, Långsrom B B, Mosskin M
J Comput Assist Tomogr. 1985 Jul-Aug;9(4):683-9. doi: 10.1097/00004728-198507010-00005.
Sixteen patients with supratentorial tumors were examined with positron emission tomography (PET) using [( 11C]methyl)-L-methionine, [11C]D-glucose, and [68Ga]EDTA as well as CT. There were nine astrocytomas (grade II), three oligoastrocytomas (grade II), two anaplastic astrocytomas (grade III), and two meningiomas. Six patients with low-grade astrocytomas and all three patients with oligoastrocytomas had an accumulation of [11C]methionine varying from slightly to intensely increased as compared with normal brain tissue. There was a markedly increased uptake of methionine in the anaplastic astrocytomas. Three of the low-grade astrocytomas had a decreased uptake of [11C]methionine in at least part of the tumor as compared with normal brain tissue. Contrast enhancement on CT or uptake of [68Ga]EDTA was not a prerequisite for increased accumulation of methionine. Uptake of [11C]glucose was lower than or equal to that of normal brain tissue in the low-grade tumors and also in one of the two anaplastic astrocytomas and in the bulk of the other. In each individual case the methionine uptake tended to be higher--or less decreased--than the glucose uptake. In the low-grade tumors the uptake of methionine and that of glucose were often different, occasionally markedly different, as far as the tumoral-peritumoral areas involved. These differences were even more remarkable in the two anaplastic astrocytomas. An increased uptake of methionine was often seen in areas appearing normal on CT. It appears that PET with [11C]glucose has limitations with regard to delineation of the low-grade astrocytomas, whereas PET with [11C]methionine usually better reflects the extent of these tumors and, to a lesser degree, the extent of the high-grade neoplasms. The results of PET with [68Ga]EDTA were similar to those with postcontrast CT in most patients. The two meningiomas exhibited a high uptake of all tracers used for PET as well as a marked contrast enhancement on CT. The extent of the meningiomas judged by PET with the various tracers correlated well with the extent assessed by postcontrast CT.
对16例幕上肿瘤患者进行了正电子发射断层扫描（PET）检查，使用了[(11C)甲基]-L-蛋氨酸、[11C]D-葡萄糖和[68Ga]乙二胺四乙酸（EDTA），同时进行了CT检查。其中有9例星形细胞瘤（Ⅱ级）、3例少突星形细胞瘤（Ⅱ级）、2例间变性星形细胞瘤（Ⅲ级）和2例脑膜瘤。6例低级别星形细胞瘤患者以及所有3例少突星形细胞瘤患者的[(11C)蛋氨酸摄取量与正常脑组织相比，有从轻度到显著增加的情况。间变性星形细胞瘤中蛋氨酸摄取量明显增加。与正常脑组织相比，3例低级别星形细胞瘤中至少部分肿瘤区域的[(11C)蛋氨酸摄取量降低。CT上的对比增强或[68Ga]EDTA的摄取并不是蛋氨酸摄取增加的必要条件。在低级别肿瘤以及2例间变性星形细胞瘤中的1例和另一例的大部分区域，[1C]葡萄糖的摄取低于或等于正常脑组织。在每个病例中，蛋氨酸摄取量往往高于或减少程度低于葡萄糖摄取量。在低级别肿瘤中，就肿瘤-瘤周区域而言，蛋氨酸摄取量和葡萄糖摄取量常常不同，偶尔差异显著。在2例间变性星形细胞瘤中，这些差异更为明显。在CT上看似正常的区域常常可见蛋氨酸摄取增加。看来，[11C]葡萄糖PET在描绘低级别星形细胞瘤方面存在局限性，而[11C]蛋氨酸PET通常能更好地反映这些肿瘤的范围，在较小程度上也能反映高级别肿瘤的范围。在大多数患者中，[68Ga]EDTA PET的结果与增强后CT的结果相似。2例脑膜瘤对用于PET的所有示踪剂摄取都很高，并且在CT上有明显的对比增强。用各种示踪剂通过PET判断的脑膜瘤范围与增强后CT评估的范围相关性良好。
