Sa'Adu A, Thomson B J, Bountiff L, Webster A D
Immune Deficiency Research Group, Clinical Research Centre, Harrow, Middlesex, UK.
Clin Exp Immunol. 1993 Jan;91(1):50-3. doi: 10.1111/j.1365-2249.1993.tb03352.x.
DNA of circulating lymphocytes obtained from 17 patients with 'common variable' immunodeficiency (CVID) was tested for the presence of HIV-1 sequences, using a variety of primers complementary to conserved regions of HIV-1 genomes. None of the patients was positive. The DNA from 12 CVID patients was tested for the presence of human herpesvirus 6 (HHV-6), using appropriate primers for this virus which is known to remain latent following primary infection in the majority of people during childhood. Similar numbers of patients and normal subjects were positive (about 30%), suggesting that CVID patients are not particularly prone to reactivation of this virus. Despite previous anecdotal reports of an unexplained association between HIV-1 and CVID, we conclude that there is no evidence that this virus is implicated in the pathogenesis of CVID. A role for HHV-6 also seems unlikely.
利用多种与HIV-1基因组保守区域互补的引物，对17例“常见变异型”免疫缺陷（CVID）患者循环淋巴细胞的DNA进行了HIV-1序列检测。所有患者检测结果均为阴性。使用针对人疱疹病毒6型（HHV-6）的合适引物，对12例CVID患者的DNA进行了HHV-6检测。已知该病毒在大多数人童年时期初次感染后会处于潜伏状态。患者和正常受试者中呈阳性的人数相近（约30%），这表明CVID患者并非特别容易出现该病毒的再激活。尽管之前有一些未经证实的报道称HIV-1与CVID之间存在无法解释的关联，但我们得出结论，没有证据表明该病毒与CVID的发病机制有关。HHV-6似乎也不太可能起作用。
