Korkusuz F, Uchida A, Shinto Y, Araki N, Inoue K, Ono K
Osaka University Medical School, Japan.
J Bone Joint Surg Br. 1993 Jan;75(1):111-4. doi: 10.1302/0301-620X.75B1.8380599.
The efficacy of locally implanted antibiotic-calcium hydroxyapatite ceramic composites was investigated for the treatment of experimentally produced, implant-related osteomyelitis in rats. High concentrations of antibiotics were detected at the site of infection and bacteria were eradicated without removal of the metal implants. Parenteral antibiotics and surgical debridement, alone or in combination with antibiotic-impregnated acrylic bone cement, all failed to eradicate the infections.
研究了局部植入抗生素-羟基磷灰石陶瓷复合材料对大鼠实验性植入相关骨髓炎的治疗效果。在感染部位检测到高浓度抗生素，且未移除金属植入物的情况下细菌被根除。单独使用静脉注射抗生素和手术清创，或与抗生素浸渍的丙烯酸骨水泥联合使用，均未能根除感染。
