A.V. Topchiev Institute of Petrochemical Synthesis RAS, Leninsky Pr. 29, 119991 Moscow, Russia.
Chemistry Department, M.V. Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russia.
Int J Mol Sci. 2021 Jul 19;22(14):7690. doi: 10.3390/ijms22147690.
In bone surgery and orthopedics, bioresorbable materials can be helpful in bone repair and countering post-op infections. Explicit antibacterial activity, osteoinductive and osteoconductive effects are essential to achieving this objective. Nonwoven electrospun (ES) fibers are receiving the close attention of physicians as promising materials for wound dressing and tissue engineering; potentially, in high contrast with dense materials, ES mats hamper regeneration of the bone extracellular matrix to a lesser extent. The use of the compositions of inherently biodegradable polyesters (poly(ε-caprolactone) PCL, poly(lactoglycolide), etc.), calcium phosphates and antibiotics is highly prospective, but the task of forming ES fibers from such compositions is complicated by the incompatibility of the main organic and inorganic ingredients, polyesters and calcium phosphates. In the present research we report the synthesis of hydroxyapatite (HAp) nanoparticles with uniform morphology, and demonstrate high efficiency of the block copolymer of PCL and poly(ethylene phosphoric acid) (PEPA) as an efficient compatibilizer for PCL/HAp mixtures that are able to form ES fibers with improved mechanical characteristics. The materials obtained in the presence of vancomycin exhibited incremental drug release against ().
在骨外科和矫形外科中，生物可吸收材料有助于骨修复和对抗术后感染。明确的抗菌活性、成骨和骨传导作用对于实现这一目标至关重要。无纺电纺（ES）纤维作为伤口敷料和组织工程的有前途的材料受到了医生的密切关注；与致密材料相比，ES 垫具有潜在的优势，对骨细胞外基质的再生的阻碍作用较小。使用固有可生物降解的聚酯（聚（ε-己内酯）PCL、聚（乳酸-乙醇酸）等）、磷酸钙和抗生素的组合物具有很高的前景，但由于主要有机和无机成分（聚酯和磷酸钙）的不兼容性，从这些组合物中形成 ES 纤维的任务变得复杂。在本研究中，我们报告了具有均匀形态的羟基磷灰石（HAp）纳米粒子的合成，并证明了 PCL 和聚（磷酸乙酯）（PEPA）嵌段共聚物作为 PCL/HAp 混合物的有效增容剂的高效性，该混合物能够形成具有改善的机械性能的 ES 纤维。在万古霉素存在下获得的材料对（）表现出递增的药物释放。
