Nyerges G, Jaszovszky S, Pintér A, Hompó Z
Dev Biol Stand. 1977;34:165-8.
The encephalitogenic property of rabies vaccines of brain tissue origin (Hempt vaccine produced in different institutes, Semple vaccine, International Standard of Rabies Vaccine) was studied in animal experiments. Guinea pigs inoculated with the vaccines in complete Freund adjuvant were observed for clinical signs and histopathological changes characteristic of experimental allergic encephalomyelitis. Normal sheep brain suspension was used as control. The minimal encephalitogenic dose of the Hempt vaccine was found about 3,500 times more than that of the control material. Hempt vaccine proved much less reactogenic than the International Standard of Rabies Vaccine and the Semple vaccine. Subsequent lots of Hempt vaccine were slightly different in respect of their encephalitogenic activity.
对脑组织来源的狂犬病疫苗（不同机构生产的亨普特疫苗、森普尔疫苗、狂犬病疫苗国际标准品）的致脑炎特性进行了动物实验研究。给豚鼠接种加有完全弗氏佐剂的疫苗，观察其是否出现实验性变应性脑脊髓炎的临床症状和组织病理学变化。用正常羊脑悬液作为对照。发现亨普特疫苗的最小致脑炎剂量比对照材料的最小致脑炎剂量高约3500倍。事实证明，亨普特疫苗的反应原性比狂犬病疫苗国际标准品和森普尔疫苗小得多。随后几批亨普特疫苗的致脑炎活性略有不同。
