Augustinský V, Svrcek S, Vrtiak O J, Benko G, Konrád V
Vet Med (Praha). 1981 Jun;26(6):353-65.
The safety and neuroallergic activity of current commercial and experimental rabies vaccine were studied by detecting the patho-histological changes in the central nervous system of laboratory animals (guinea-pigs) according to the method recommended by the World Health Organization (Gispen, 1975). Six rabies vaccines were tested in the experiments. The vaccines are as follows: lyophilized rabies vaccine - human; lyophilized rabies vaccine - veterinary; rabies vaccine U. S. P. duck embryo - human; avianized rabies vaccine - veterinary; inactivated rabies vaccine from strain Vnukov-32 - human; live cell rabies vaccine from strain Vnukovo-32 - veterinary. Patho-histological changes indicating the neuroallergic activity of the vaccines were observed in laboratory animals (varying range and intensity of these activities, to which the following vaccines were applied: lyophilized vaccine - veterinary and lyophilized rabies vaccine - human. The cell rabies vaccines from strain Vnukovo-32 were found to be safe; they can be recommended for their merits (including nonreactogenicity) to be used in veterinary practice in rabies immunoprophylaxis.
根据世界卫生组织推荐的方法（吉斯彭，1975年），通过检测实验动物（豚鼠）中枢神经系统的病理组织学变化，对目前市售和实验用狂犬病疫苗的安全性和神经变态反应活性进行了研究。实验中测试了六种狂犬病疫苗。这些疫苗如下：冻干人用狂犬病疫苗；冻干兽用狂犬病疫苗；美国药典鸭胚狂犬病疫苗 - 人用；禽化狂犬病疫苗 - 兽用；Vnukov - 32株灭活狂犬病疫苗 - 人用；Vnukovo - 32株活细胞狂犬病疫苗 - 兽用。在实验动物中观察到了表明疫苗神经变态反应活性的病理组织学变化（这些活性的范围和强度各不相同，以下疫苗呈现出这些变化：冻干兽用狂犬病疫苗和冻干人用狂犬病疫苗。发现Vnukovo - 32株细胞狂犬病疫苗是安全的；鉴于其优点（包括无反应原性），可推荐用于兽医狂犬病免疫预防实践。
