Lugosi L, Drinóczy M
Dev Biol Stand. 1977;34:189-91.
Numerous laboratory experiments and field trials for tuberculosis prevention have been analyzed. The results concern the comparison of different BCG strains, the correlation between the protection and allergenic property and the degree of residual virulence as an inherited character in producing post vaccination side effects. There are more and more reports about incidence of side effects following BCG immunostimulation. We used the French, Glaxo and International Reference (Japan) strains for this toxicity test because these are the most used strains for vaccine production. The differences obtained in toxic effects of the three tested BCG strains in this experimental model suggest that the investigations should be continued and comparative analyses with histological and immunochemical methods should be extended.
对众多结核病预防的实验室实验和现场试验进行了分析。结果涉及不同卡介苗菌株的比较、保护作用与致敏特性之间的相关性以及作为产生接种后副作用的遗传特征的残余毒力程度。关于卡介苗免疫刺激后副作用发生率的报告越来越多。我们使用法国株、葛兰素株和国际参考株（日本）进行了这项毒性试验，因为这些是疫苗生产中最常用的菌株。在该实验模型中，三种受试卡介苗菌株的毒性作用所获得的差异表明，研究应继续进行，并且应扩大组织学和免疫化学方法的比较分析。
