衰老过程中纹状体D2多巴胺受体mRNA合成减少。
Decreased striatal D2 dopamine receptor mRNA synthesis during aging.
作者信息
Mesco E R, Carlson S G, Joseph J A, Roth G S
机构信息
Molecular Physiology and Genetics Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
出版信息
Brain Res Mol Brain Res. 1993 Jan;17(1-2):160-2. doi: 10.1016/0169-328x(93)90085-4.
Decreases in striatal dopamine receptors during aging are related to deficits in motor functions, and are highly correlated with the D2 receptor subtype. Some receptor loss is attributed to cell death, while the remainder is thought to be related to synthetic capacity. We discuss here our findings, for isolated rat striatal nuclei, which indicate a 50% overall decrease in the synthesis of the dopamine D2 mRNA in aged nuclei.
衰老过程中纹状体多巴胺受体的减少与运动功能缺陷有关，且与D2受体亚型高度相关。一些受体丧失归因于细胞死亡，而其余部分则被认为与合成能力有关。我们在此讨论针对分离的大鼠纹状体核的研究结果，这些结果表明老年核中多巴胺D2 mRNA的合成总体下降了50%。
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