Age-related decrease in responsiveness to L-DOPA is not due to changes in dopamine receptor mRNAs or G protein mRNAs.
作者信息
Murata M, Aihara Y, Yamanouchi H, Yamada S, Kanazawa I
机构信息
Department of Neurology, School of Medicine, University of Tokyo, Japan.
出版信息
J Neural Transm (Vienna). 1996;103(3):343-8. doi: 10.1007/BF01271245.
PMID:8739845
Abstract
To clarify the cause of the age-related decrease in the responsiveness to L-DOPA seen in parkinsonian patients, we studied age-related changes in the mRNA levels of dopamine receptors (D1, D2) and of G proteins (Gs, Gi, Go) in 22 control human brains aged 50-105 years. Neither the mRNA levels of dopamine receptors or of the G proteins changed with age. Another factor in the receptor-G protein cascade, such as guanine nucleotide binding, may cause the age-related decrease in responsiveness.
摘要
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