Tsuzaka K, Ogasawara T, Tojo T, Fujii H, Tsukatani Y, Kubo A, Homma M
Department of Internal Medicine, School of Medicine, Keio University, Japan.
Scand J Rheumatol. 1993;22(1):1-9. doi: 10.3109/03009749309095103.
Glandular function as estimated by salivary function scintigraphy and extraglandular manifestations were compared among 174 Sjögren's syndrome (SS) patients according to their anti-Ro/SSA, anti-La/SSB, and anti-U1RNP autoantibody status, to clarify the relationship between these autoantibodies and clinical parameters in SS. These antibodies were detected by RNA-immunoprecipitation. Anti-La/SSB or only anti-Ro/SSA antibody was common in 84 primary SS (P-SS) patients, whereas the frequency of only anti-U1RNP was high in 90 secondary SS (S-SS) patients, especially in those with systemic lupus erythematosus (SLE). Antibody-negativity was common in SS with rheumatoid arthritis and was also found in 33% of P-SS. In P-SS, salivary gland dysfunction and parotid swelling were severe in patients who had serological abnormalities with anti-Ro/SSA and with or without anti-La/SSB. They were mild in antibody-negative patients who had mild extraglandular symptoms and in patients with only anti-U1RNP antibody who had Raynaud's phenomenon, pulmonary fibrosis, and later disease onset. P-SS patients positive for both anti-Ro/SSA and anti-U1RNP had SLE-like features. SS could be classified clinically according to these autoantibodies.
根据抗Ro/SSA、抗La/SSB和抗U1RNP自身抗体状态，对174例干燥综合征（SS）患者的唾液腺功能闪烁扫描评估的腺体功能和腺体外表现进行比较，以阐明这些自身抗体与SS临床参数之间的关系。这些抗体通过RNA免疫沉淀法检测。抗La/SSB或仅抗Ro/SSA抗体在84例原发性SS（P-SS）患者中常见，而仅抗U1RNP的频率在90例继发性SS（S-SS）患者中较高，尤其是在系统性红斑狼疮（SLE）患者中。抗体阴性在合并类风湿关节炎的SS中常见，在33%的P-SS患者中也有发现。在P-SS中，抗Ro/SSA血清学异常且伴有或不伴有抗La/SSB的患者唾液腺功能障碍和腮腺肿大严重。在腺体外症状较轻的抗体阴性患者以及仅抗U1RNP抗体且有雷诺现象、肺纤维化和疾病起病较晚的患者中，这些症状较轻。抗Ro/SSA和抗U1RNP均阳性的P-SS患者具有SLE样特征。SS可根据这些自身抗体进行临床分类。
