Mavragani C P, Tzioufas A G, Moutsopoulos H M
Department of Pathophysiology, School of Medicine, National University of Athens, Greece.
Int Arch Allergy Immunol. 2000 Sep;123(1):46-57. doi: 10.1159/000024423.
Autoantibodies to cellular autoantigens are usually found in sera of patients with systemic autoimmune rheumatic diseases. Patients with Sjögren's syndrome (SS) frequently present autoantibodies to both organ and non-organ-specific autoantigens. The most commonly detected autoantibodies are those directed against the ribonucleoproteins Ro/SSA and La/SSB. The presence of the antibodies in SS is associated with early disease onset, longer disease duration, parotid gland enlargement, higher frequency of extraglandular manifestations and more intense lymphocytic infiltration of the minor salivary glands. Over the past several years, the structure and function of these autoantigens have been extensively studied. Several centers, using different techniques, have investigated the B cell epitopes on the protein components Ro 60 kD, Ro 52kD, and La 48 kD. Finally, increased evidence of direct involvement of anti-Ro/SSA and anti-La/SSB autoantibodies in the pathogenesis of tissue injury has been contributed by several studies.
细胞自身抗原的自身抗体通常在系统性自身免疫性风湿病患者的血清中被发现。干燥综合征（SS）患者经常出现针对器官特异性和非器官特异性自身抗原的自身抗体。最常检测到的自身抗体是针对核糖核蛋白Ro/SSA和La/SSB的抗体。SS中这些抗体的存在与疾病早期发作、病程延长、腮腺肿大、腺外表现的更高频率以及小唾液腺更强烈的淋巴细胞浸润有关。在过去几年中，这些自身抗原的结构和功能得到了广泛研究。几个中心使用不同技术研究了蛋白质成分Ro 60 kD、Ro 52 kD和La 48 kD上的B细胞表位。最后，几项研究提供了越来越多的证据，证明抗Ro/SSA和抗La/SSB自身抗体直接参与组织损伤的发病机制。
