Alché L E, Coto C E
Department of Biochemistry, School of Science, University of Buenos Aires, Argentine.
Arch Virol. 1993;128(3-4):389-94. doi: 10.1007/BF01309449.
The establishment of an experimental persistent infection with Junin virus, the aetiological agent of argentine hemorrhagic fever, involves the emergence of antigenic variants in brain and blood of the cricetid Calomys musculinus. We demonstrate that antigenic variants can also be isolated in vitro under the selective pressure of polyclonal antibodies and from a long-term infected C. musculinus primary embryo fibroblast culture. The participation of neutralizing antibodies and host cells in the appearance of viral variants in vivo is discussed.
阿根廷出血热的病原体胡宁病毒实验性持续感染的建立，涉及仓鼠科小家鼠的脑和血液中抗原变异体的出现。我们证明，在多克隆抗体的选择压力下，以及从长期感染的小家鼠原代胚胎成纤维细胞培养物中，也可以在体外分离出抗原变异体。本文讨论了中和抗体和宿主细胞在体内病毒变异体出现过程中的作用。
