Peralta L A, Laguens R P, Cossio P M, Sabattini M S, Maiztegui J I, Arana R M
Intervirology. 1979;11(2):111-6. doi: 10.1159/000149021.
Calomys musculinus, a wild cricetid rodent, is one of the main reservoirs of Junin virus. Six of these animals were infected by being placed in close contact with animals that had been experimentally infected with the virus. They were sacrificed at 10, 15 and 20 months after contact, and their salivary glands were studied by ultrastructural, immunohistochemical and virological methods. Two animals developed chronic viremia and low titers of complement-fixing antibodies. These animals were the only ones that had high viral titers in salivary glands and blood and viral antigen and particles in salivary glands. Although some of the other animals had viremia at the beginning of the experiment, it was absent 5 months later. Complement-fixing antibodies developed in all animals. On the basis of these findings, we assumed that the salivary gland is an important site of viral synthesis and excretion. This type of chronic infection, with persistent viremia and virus shedding, is possibly important for virus perpetuation in nature and transmission to man.
小家鼠（Calomys musculinus）是一种野生仓鼠科啮齿动物，是胡宁病毒的主要宿主之一。将其中6只动物与经实验感染该病毒的动物密切接触，使其感染。在接触后的10、15和20个月将它们处死，并通过超微结构、免疫组织化学和病毒学方法对其唾液腺进行研究。2只动物出现慢性病毒血症和低滴度补体结合抗体。这些动物是仅有的在唾液腺和血液中具有高病毒滴度以及在唾液腺中具有病毒抗原和病毒颗粒的动物。尽管其他一些动物在实验开始时出现了病毒血症，但5个月后病毒血症消失。所有动物均产生了补体结合抗体。基于这些发现，我们推测唾液腺是病毒合成和排泄的重要部位。这种伴有持续性病毒血症和病毒脱落的慢性感染类型，可能对病毒在自然界中的持续存在和传播给人类具有重要意义。
