Hanson W R, Osborne J W, Sharp J G
Gastroenterology. 1977 Apr;72(4 Pt 1):692-700.
Thirty days after resection of 10 to 80% of the midportion of the small intestine, excluding the duodenum, several cell kinetic parameters were investigated in the residual intestine. The degree of intestinal response increased in a stepwise fashion as the amount of tissue removed was increased. The response involved marked increases in: DNA synthesis per crypt expressed as disintegrations per minute of tritium (3H) reflecting (3H)thymidine incorporation, cells per crypt column, 3H-labelled cells per crypt column, cells per villus column, and thickness of all intestinal wall components. These changes occureed throughout the small intestine even at lesser resections. ""Crypt profiles'' reflected changes in cell counts, but when the labeling frequency of proliferative cells was expressed as a percentage of the total crypt height, there was no change. The total number of crypts in the duodenum remained unchanged and the total number of cyrpts in the residual jejunum plus ileum decreased proportionally to the amount of tissue removed. Intestinal compensation occurred by increasing the size of the structures present in the residual intestine, not by increasing the number of structural units.
在切除10%至80%的小肠中段（不包括十二指肠）30天后，对残留小肠的几个细胞动力学参数进行了研究。随着切除组织量的增加，肠道反应程度呈逐步增加。这种反应包括以下显著增加：每个隐窝的DNA合成，以反映氚（3H）胸腺嘧啶核苷掺入的每分钟氚（3H）衰变表示；每个隐窝柱的细胞数；每个隐窝柱的3H标记细胞数；每个绒毛柱的细胞数；以及所有肠壁成分的厚度。即使在较小切除量时，这些变化也发生在整个小肠。“隐窝形态”反映了细胞计数的变化，但当增殖细胞的标记频率表示为隐窝总高度的百分比时，则没有变化。十二指肠中隐窝的总数保持不变，残留空肠加回肠中隐窝的总数与切除组织量成比例减少。肠道的代偿是通过增加残留小肠中现有结构的大小，而不是通过增加结构单位的数量来实现的。
