Martyn C N, Cruddas M, Compston D A
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK.
J Neurol Neurosurg Psychiatry. 1993 Feb;56(2):167-8. doi: 10.1136/jnnp.56.2.167.
In a case-control study of 214 patients with multiple sclerosis, recall of infectious mononucleosis in subjects seropositive for Epstein-Barr viral capsid antigen was associated with a relative risk of 2.9 (95% CI 1.1 to 7.2). Those who reported having infectious mononucleosis before the age of 18 years had a relative risk of multiple sclerosis of 7.9 (95% CI 1.7 to 37.9). The pathogenesis of multiple sclerosis may involve an age-dependent host response to Epstein-Barr virus infection.
在一项针对214例多发性硬化症患者的病例对照研究中，对于爱泼斯坦-巴尔病毒衣壳抗原血清阳性的受试者，既往感染传染性单核细胞增多症与相对风险2.9相关（95%置信区间为1.1至7.2）。那些报告在18岁之前患过传染性单核细胞增多症的患者，患多发性硬化症的相对风险为7.9（95%置信区间为1.7至37.9）。多发性硬化症的发病机制可能涉及宿主对爱泼斯坦-巴尔病毒感染的年龄依赖性反应。
