Operskalski E A, Visscher B R, Malmgren R M, Detels R
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90032.
Neurology. 1989 Jun;39(6):825-9. doi: 10.1212/wnl.39.6.825.
We conducted a study of 145 persons with multiple sclerosis who had been identified in a 1970 survey and 145 friend controls, to investigate whether the development of MS was associated with exposure to uncommon viruses or an older age at infection with 1 or more common viruses. The most striking finding was a strong positive association for history of infectious mononucleosis (IM), suggesting older age at exposure to Epstein-Barr virus, the most common etiologic agent of IM. We also found significant positive associations for number of different domiciles before adulthood and for visits outside the United States; both would be compatible with an increased likelihood among cases of exposures to uncommon viruses or to multiple strains of a common agent. Cases were younger at menarche, increasing the probability of viral exposure after puberty.
我们对1970年一项调查中确定的145名多发性硬化症患者和145名作为对照的朋友进行了研究，以调查多发性硬化症的发病是否与接触不常见病毒或感染一种或多种常见病毒时年龄较大有关。最显著的发现是传染性单核细胞增多症（IM）病史存在强烈的正相关，这表明感染爱泼斯坦-巴尔病毒（IM最常见的病原体）时年龄较大。我们还发现，成年前居住过的不同住所数量以及赴美访问次数均存在显著的正相关；这两者都与病例接触不常见病毒或一种常见病原体的多种毒株的可能性增加相符。病例月经初潮时年龄较小，增加了青春期后接触病毒的可能性。
