Klausen B, Apostolopoulos A, Stoltze K, Nörgaard F
Department of Periodontology, Royal Dental College, Copenhagen, Denmark.
Scand J Dent Res. 1993 Feb;101(1):33-6. doi: 10.1111/j.1600-0722.1993.tb01642.x.
LongoVital is a herbal tablet with documented immunostimulatory effects in man. In the present study the effect of LongoVital on development of periodontal disease was investigated in a rat model. Fifty-four conventional rats, 5 wk old, were distributed into the following groups: A) untreated, uninfected; B) untreated, infected with Actinomyces viscosus and Porphyromonas gingivalis wk 8; C) treated with LongoVital 80 mg x 3/wk, wk 5-14, uninfected; D) treated with LongoVital 80 mg x 3/wk, wk 5-14, infected with A. viscosus and P. gingivalis wk 8; E) treated with LongoVital 200 mg x 1 in wk 8 and 80 mg wk 9-14, uninfected; F) infected with A. viscosus and P. gingivalis wk 8, subsequently treated with LongoVital 200 mg x 1 in wk 8 and 80 mg wk 9-14. All animals were killed when they were 15 wk old, and periodontal bone support was assessed radiographically. Statistically significant bone loss was found in untreated, infected rats, as compared with untreated, uninfected rats. In LongoVital-treated animals, no significant difference was seen in bone level between infected and uninfected rats. These results indicate that LongoVital-treated rats were protected against periodontal bone loss caused by infection with A. viscosus and P. gingivalis. Furthermore, the protection seemed effective both when LongoVital was administered prophylactically and after exposure to periodontal pathogens. The active components of LongoVital, as well as the mechanisms responsible for the protection, remain obscure.
龙活素是一种对人体具有免疫刺激作用记录的草药片剂。在本研究中，在大鼠模型中研究了龙活素对牙周疾病发展的影响。将54只5周龄的普通大鼠分为以下几组：A）未治疗、未感染；B）未治疗，第8周感染粘性放线菌和牙龈卟啉单胞菌；C）第5 - 14周每周3次给予80毫克龙活素治疗，未感染；D）第5 - 14周每周3次给予80毫克龙活素治疗，第8周感染粘性放线菌和牙龈卟啉单胞菌；E）第8周给予200毫克龙活素单次治疗，第9 - 14周每周给予80毫克，未感染；F）第8周感染粘性放线菌和牙龈卟啉单胞菌，随后第8周给予200毫克龙活素单次治疗，第9 - 14周每周给予80毫克。所有动物在15周龄时处死，通过放射照相评估牙周骨支持情况。与未治疗、未感染的大鼠相比，未治疗、感染的大鼠出现了统计学上显著的骨质流失。在接受龙活素治疗的动物中，感染和未感染大鼠的骨水平没有显著差异。这些结果表明，接受龙活素治疗的大鼠可免受粘性放线菌和牙龈卟啉单胞菌感染引起的牙周骨流失。此外，无论是预防性给予龙活素还是在暴露于牙周病原体后给予，这种保护似乎都是有效的。龙活素的活性成分以及负责这种保护的机制仍不清楚。
