Elö J, Bajtai A, Hidvégi J, Lábas Z
Department of Oto-Rhino-Laryngology, Uzsoki Municipal Hospital, Budapest, Hungary.
Eur Arch Otorhinolaryngol. 1993;249(8):499-502. doi: 10.1007/BF00168865.
Synovial sarcoma in an extra-articular location is a very rare tumor, particularly in relation to childhood tumors. We report our experiences with an 11-year-old boy who suffered from swallowing difficulties caused by a polypoid tumor of the hypopharynx. Biopsy demonstrated a fusocellular carcinoma, while the epithelial components showed cytokeratin and neuron-specific enolase positivity. A correct final diagnosis could only be established by the histology of the surgical preparation following partial laryngopharyngectomy. The presence of spindle cells associated with glandular-like ones proved the synovial character of the tumor. The spindle cells were negative for epithelial marker but were positive for vimentin. S-100 protein positivity could only be demonstrated in the nerve elements encapsulated in the tumor. Ultrastructural examinations confirmed the presence of the different cell types. The spindle cells were rich in intermediate fibers, as demonstrated by electron microscopy.
关节外部位的滑膜肉瘤是一种非常罕见的肿瘤，尤其是在儿童肿瘤中。我们报告了一名11岁男孩的病例，他因下咽息肉样肿瘤出现吞咽困难。活检显示为梭形细胞癌，而上皮成分显示细胞角蛋白和神经元特异性烯醇化酶阳性。只有通过部分喉咽切除术后手术标本的组织学检查才能做出正确的最终诊断。梭形细胞与腺样细胞并存证实了肿瘤的滑膜特征。梭形细胞上皮标志物阴性，但波形蛋白阳性。仅在肿瘤包裹的神经成分中显示S-100蛋白阳性。超微结构检查证实了不同细胞类型的存在。电子显微镜显示梭形细胞富含中间纤维。
