Roth J A, Enzinger F M, Tannenbaum M
Cancer. 1975 Apr;35(4):1243-53. doi: 10.1002/1097-0142(197504)35:4<1243::aid-cncr2820350432>3.0.co;2-a.
This article reviews the clinicopathologic features and the biological behavior of 24 cases of synovial sarcoma that took origin from the cervical prevertebral connective tissue space and manifested as a retropharyngeal tumor or as a palpable mass in the anterior or posterior cervical triangle. The age of the 24 patients ranged from 10 to 51 years, with a median of 19 years. Ten patients were women and 14 men. Hoarseness or difficulty in breathing or swallowing were the first symptoms in eight patients. The tumors were solitary and ranged from 2 to 10 cm in greatest dimension. Microscopically, all of the cases showed the characteristic biphasic cellular pattern of a synovial sarcoma, with epithelioid and fibrosarcoma-like areas in varying proportions. Synovioblastic origin of the neoplasm was confirmed by the results of histochemical staining procedures and, in 1 case, by the examination with the electron microscope. Of the 21 cases followup information, 12 had died (10 with pulmonary metastasis) and 9 were alive and free of symptoms. Prompt and complete surgical removal is required to prevent complications from recurrent tumor growth or metastasis.
本文回顾了24例起源于颈椎前结缔组织间隙、表现为咽后肿瘤或颈部前后三角区可触及肿块的滑膜肉瘤的临床病理特征及生物学行为。24例患者年龄为10至51岁，中位年龄19岁。10例为女性，14例为男性。8例患者首发症状为声音嘶哑、呼吸或吞咽困难。肿瘤均为单发，最大直径2至10厘米。镜下，所有病例均显示滑膜肉瘤特征性的双相细胞模式，上皮样和纤维肉瘤样区域比例各异。肿瘤的滑膜母细胞起源通过组织化学染色程序结果得以证实，1例通过电子显微镜检查得以证实。在21例有随访信息的病例中，12例死亡（10例有肺转移），9例存活且无症状。需要及时彻底手术切除以防止肿瘤复发或转移引起的并发症。
