Koretz R L, Brezina M, Polito A J, Quan S, Wilber J, Dinello R, Gitnick G
Department of Medicine, University of California, Los Angeles.
Hepatology. 1993 Mar;17(3):361-5.
Using assays to detect antibodies against antigens (C-100, 5-1-1, C-22 and C-33) of the hepatitis C virus, we tested stored sera from 40 patients prospectively identified as having non-A, non-B posttransfusion hepatitis. The 28 patients who demonstrated seroconversion ("documented hepatitis C") had more severe initial disease; all 20 cases of chronic hepatitis occurred in this subgroup. Only 2 of the 12 patients who did not demonstrate such seroconversion even had symptoms. In the group of patients with documented hepatitis C, chronic hepatitis was more commonly seen in men (89%) than in women (40%). The patients in whom antibody to the C-100 antigen developed were younger and had received more blood than had those patients who had hepatitis C diagnosed by demonstration of antibodies to the 5-1-1, C-22 or C-33 antigen (or all three). The proportion of cases of posttransfusion hepatitis that could be associated with antibody sero-conversion decreased around the time that blood banks switched to an all-volunteer system. The hepatitis seen in patients who failed to demonstrate serological evidence of hepatitis C virus exposure was usually clinically unimportant; it may or may not have been due to viral infection.
我们运用检测丙型肝炎病毒抗原（C-100、5-1-1、C-22和C-33）抗体的检测方法，对40例经前瞻性鉴定为患有非甲非乙型输血后肝炎患者的储存血清进行了检测。28例出现血清转化的患者（“确诊丙型肝炎”）初始疾病更为严重；所有20例慢性肝炎病例均出现在该亚组中。在12例未出现这种血清转化的患者中，只有2例有症状。在确诊丙型肝炎的患者组中，慢性肝炎在男性（89%）中比在女性（40%）中更为常见。出现C-100抗原抗体的患者比那些通过检测5-1-1、C-22或C-33抗原（或全部三种）抗体而确诊丙型肝炎的患者更年轻，接受的输血也更多。在血库转向全志愿供血系统前后，与抗体血清转化相关的输血后肝炎病例比例有所下降。在未显示丙型肝炎病毒暴露血清学证据的患者中出现的肝炎通常在临床上并不重要；其可能是或可能不是由病毒感染引起的。
