Akashi Y, Koreeda C, Mizuno T, Inoue K, Kawa S K, Tanaka Y
Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Invest Radiol. 1993 Feb;28(2):128-32. doi: 10.1097/00004424-199302000-00009.
The influence of lipiodol injection on hepatic morphology and function was investigated in 119 rabbits with hepatic VX2 tumors.
The rabbits were divided into the following three groups, according to the materials injected via the proper hepatic artery: group 1 received doxorubicin (Adriamycin [ADM]); group 2 received lipiodol (LPD); and group 3 received LPD plus ADM. Groups 2 and 3 were each divided into three subgroups, according to the dose of LPD injected (0.3, 0.6, and 1.2 mL). Non-tumorous regions in the tumor-bearing lobe and the tumor-free lobe were examined histologically; low-kilovolt x-ray studies and computed tomography (CT) also were performed in 84 rabbits. Liver function tests were performed in 35 rabbits.
Elevation of the serum aminotransferase levels was observed after the administration of LPD. Hepatocellular degeneration was marked in the tumor-free lobe, but was much more severe in the tumor-bearing lobe in groups 2 and 3. The degree of degeneration depended on the dose of LPD. Both low-kilovolt x-ray studies and CT showed the heavy accumulation of LPD in the tumor-bearing lobe.
The current study shows that the histologic and functional adverse effects of oily chemoembolization depend on the dose of LPD administered to the liver.
在119只患有肝VX2肿瘤的兔子中研究了碘油注射对肝脏形态和功能的影响。
根据经肝固有动脉注射的物质，将兔子分为以下三组：第1组接受阿霉素（阿霉素[ADM]）；第2组接受碘油（LPD）；第3组接受LPD加ADM。根据注射的LPD剂量（0.3、0.6和1.2 mL），将第2组和第3组各分为三个亚组。对荷瘤叶和无瘤叶的非肿瘤区域进行组织学检查；还对84只兔子进行了低千伏X线研究和计算机断层扫描（CT）。对35只兔子进行了肝功能测试。
注射LPD后观察到血清转氨酶水平升高。在无瘤叶中可见明显的肝细胞变性，但在第2组和第3组的荷瘤叶中更为严重。变性程度取决于LPD的剂量。低千伏X线研究和CT均显示LPD在荷瘤叶中大量积聚。
当前研究表明，油性化疗栓塞的组织学和功能不良影响取决于给予肝脏的LPD剂量。
