Akashi Y, Koreeda C, Enomoto S, Nishimura T, Tateiwa J, Mizuno T, Inoue K, Koreeda T, Ha-Kawa S K
Third Department of Internal Medicine, Kansai Medical University.
Nihon Igaku Hoshasen Gakkai Zasshi. 1991 Mar 25;51(3):289-91.
The effect of Lipiodol (LPD) on the hepatic parenchyma bearing VX2 tumor was investigated in 12 rabbits. In these rabbits Adriamycin (ADM) soluble Urografin and LPD were injected through the hepatic artery. As the control another 12 rabbits bearing VX2 tumor which were intraarterially injected with ADM solution in saline were used. Liver function tests revealed significantly higher values of serum transaminases in the LPD group than in the control group. Histologically in the LPD group, hepatocellular degeneration was observed and the severity was at its peak 3 days after injection whereas control animals preserved almost normal structure. The degeneration of the tumor-bearing lobe was more severe than that of the tumor-free lobe. This study showed the histologically and functionally demonstrable adverse effects of LPD.
在12只兔中研究了碘油（LPD）对荷VX2肿瘤肝实质的影响。对这些兔经肝动脉注射阿霉素（ADM）、可溶性泛影葡胺和LPD。作为对照，使用另外12只荷VX2肿瘤的兔，经动脉注射阿霉素盐溶液。肝功能检查显示LPD组血清转氨酶值显著高于对照组。组织学上，LPD组观察到肝细胞变性，注射后3天严重程度达到峰值，而对照动物的结构几乎正常。荷瘤叶的变性比无瘤叶更严重。本研究显示了LPD在组织学和功能上可证实的不良反应。
