Tabaru K, Konno T, Oda T, Nagamitsu A, Ishimaru Y, Kitamura N
First Department of Surgery, Kumamoto University School of Medicine, Japan.
Cancer Chemother Pharmacol. 2001;47(2):149-54. doi: 10.1007/s002800000209.
Long-term survival and cure cannot be achieved in patients with unresectable, advanced abdominal cancer, because no chemotherapeutic treatment has definite antitumor activity for malignant solid tumor and its dissemination. In this study, arterial and intraperitoneal administration of oily anticancer agents, which have properties that permit targeted chemotherapy for VX2 carcinoma implanted in the liver, was attempted to achieve long-term survival.
Rabbits bearing VX2 tumors in the liver measuring 1-2 cm in diameter received an arterial injection of 0.2 ml of nitrogen mustard N-Oxide (HN2-O) dissolved in Lipiodol (7.5 mg/ml), a newly developed oily anticancer agent, for the tumor and an intraperitoneal injection of a cocktail of oily anticancer agents for the prevention of intraperitoneal dissemination.
Twelve out of thirteen rabbits survived and VX2 cancer was not observed in these 12 rabbits. The controls received a sham operation, an intraperitoneal injection of the cocktail of oily anticancer agents alone, or an arterial injection of HN2-O/Lipiodol alone. In these control groups, 27 out of 29 rabbits died of cancer. To examine the dose form for arterial injection, 14 rabbits received an arterial injection of the simple mixture of HN2-O dissolved in physiological saline and Lipiodol, with an additional intraperitoneal injection of the cocktail. Eight of these 14 rabbits died of enlargement of the hepatic tumor and peritoneal dissemination.
Long-term survival and cure was achieved in almost all rabbits bearing VX2 tumor in the liver by simultaneous arterial and intraperitoneal injection of oily anticancer agents.
无法切除的晚期腹部癌症患者无法实现长期生存和治愈，因为没有化疗方法对恶性实体瘤及其扩散具有明确的抗肿瘤活性。在本研究中，尝试通过动脉和腹腔内给予油性抗癌药物来实现长期生存，这些油性抗癌药物具有对植入肝脏的VX2癌进行靶向化疗的特性。
肝脏中携带直径为1 - 2厘米VX2肿瘤的兔子接受动脉注射0.2毫升溶解在碘油（7.5毫克/毫升）中的氮芥N - 氧化物（HN2 - O），这是一种新开发的油性抗癌药物，用于治疗肿瘤，并腹腔内注射油性抗癌药物混合物以预防腹腔内扩散。
13只兔子中有12只存活，且在这12只兔子中未观察到VX2癌。对照组接受假手术、单独腹腔内注射油性抗癌药物混合物或单独动脉注射HN2 - O/碘油。在这些对照组中，29只兔子中有27只死于癌症。为了研究动脉注射的剂型，14只兔子接受动脉注射溶解在生理盐水中的HN2 - O和碘油的简单混合物，并额外腹腔内注射该混合物。这14只兔子中有8只死于肝肿瘤增大和腹膜扩散。
通过同时进行动脉和腹腔内注射油性抗癌药物，几乎所有肝脏中携带VX2肿瘤的兔子都实现了长期生存和治愈。
