Gauer F, Masson-Pévet M, Pévet P
Neurobiologie des Fonctions Rythmiques et Saisonnières, URA-CNRS 1332, Université Louis Pasteur, Strasbourg, France.
Brain Res. 1993 Jan 29;602(1):153-6. doi: 10.1016/0006-8993(93)90256-m.
The pineal hormone melatonin interacts with the neuroendocrine system via high affinity binding sites. The density of these receptors is increased after 72 h constant light or pinealectomy in both rat pars tuberalis and suprachiasmatic nuclei. The present results show that, in rat PT and SCN, this increase can be inversed by a single melatonin injection (50 micrograms s.c. in 0.1 ml NaCl, 4 h before sacrifice). At the time of sacrifice, plasma melatonin concentrations of injected animals were no longer significantly different when compared to control values. Thus, this observed effect is not a result of a receptor occupation, but demonstrates a direct regulation of melatonin receptors by melatonin itself.
松果体激素褪黑素通过高亲和力结合位点与神经内分泌系统相互作用。在大鼠结节部和视交叉上核中，持续光照72小时或松果体切除后，这些受体的密度会增加。目前的结果表明，在大鼠结节部和视交叉上核中，单次注射褪黑素（在0.1毫升氯化钠中皮下注射50微克，在处死前4小时）可使这种增加逆转。在处死时，与对照值相比，注射动物的血浆褪黑素浓度不再有显著差异。因此，观察到的这种效应不是受体占据的结果，而是褪黑素自身对褪黑素受体的直接调节。
