淋巴结及结外非霍奇金淋巴瘤中的EBV DNA：细胞谱系、形态学及起源部位的影响

EBV DNA in nodal and extranodal non-Hodgkin's lymphomas: impact of cell lineage, morphology, and site of origin.

作者信息

Ott G, Ott M, Müller-Hermelink H K

机构信息

Pathologisches Institut, Universität Würzburg, Germany.

出版信息

Toxicol Lett. 1993 Apr;67(1-3):341-51. doi: 10.1016/0378-4274(93)90067-8.

DOI:10.1016/0378-4274(93)90067-8

PMID:8383891

Abstract

The Epstein-Barr virus (EBV) is a transforming herpes virus which is found in high frequencies in lymphoproliferative disorders arising in immunocompromised patients. To address the question of viral involvement in lymphomas of immunocompetent patients, we investigated 299 nodal and extranodal non-Hodgkin's, non-Burkitt's lymphomas of B- and T-cell lineage for the presence of EBV DNA. Epstein-Barr nucleic acid sequences were detected in 23 of 226 (10%) cases of B-cell lymphomas, in 24/72 (33%) T-cell lymphomas and one non-B, non-T lymphoma. Our data imply a possible role for the EBV in lymphoma development or propagation, an influence of viral factors on morphology and an impact of the anatomic site in which lymphoma development occurs.

摘要

爱泼斯坦-巴尔病毒（EBV）是一种具有转化能力的疱疹病毒，在免疫功能低下患者发生的淋巴增殖性疾病中高频率出现。为了探讨病毒是否参与免疫功能正常患者淋巴瘤的发生，我们对299例B细胞和T细胞系的淋巴结及结外非霍奇金、非伯基特淋巴瘤进行了研究，以检测EBV DNA的存在情况。在226例B细胞淋巴瘤中的23例（10%）、72例T细胞淋巴瘤中的24例（33%）以及1例非B非T淋巴瘤中检测到了爱泼斯坦-巴尔核酸序列。我们的数据表明EBV在淋巴瘤发生或发展过程中可能发挥作用，病毒因素对形态有影响，且淋巴瘤发生的解剖部位也有影响。