Andrianov G N, Akoev G N, Braun H A, Ryzhova I V, Voigt K H, Sherman N O
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Neuroreport. 1993 Jan;4(1):53-4. doi: 10.1097/00001756-199301000-00013.
In the present study we have shown by single afferent unit recording in electroreceptors of skates (the ampullae of Lorenzini) that the synthetic analogue of leu-enkephalin, dalargin (DAL) at concentrations between 10(-6)-10(-10) M cause a concentration-dependent decrease in the resting discharge frequency as well as a decrease in stimulus evoked responses. The specific opiate antagonist naloxone (NAL, 10(-6) M) antagonizes responses induced by DAL. DAL depresses the excitatory action of L-glutamate (L-GLU). The data obtained speak in favour of the presence of opiate receptors at the synaptic membrane of the ampullae of Lorenzini.
