腺相关病毒：在特定染色体位点的整合。
Adeno-associated virus: integration at a specific chromosomal locus.
作者信息
Samulski R J
机构信息
Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.
出版信息
Curr Opin Genet Dev. 1993 Feb;3(1):74-80. doi: 10.1016/s0959-437x(05)80344-2.
PMID:8384035
Abstract
Recent characterization of integration of the human parvovirus, adeno-associated virus, has uncovered the exciting occurrence of targeted integration. Thus far, such specific integration has been found to be unique among the eukaryotic viruses. The molecular details of the steps involved in virus integration are actively being pursued and should yield significant information for our understanding of the mechanisms of DNA transposition.
摘要
最近对人类细小病毒——腺相关病毒整合的特征描述，揭示了靶向整合这一令人兴奋的现象。到目前为止，这种特异性整合在真核病毒中是独一无二的。病毒整合所涉及步骤的分子细节正在积极研究中，有望为我们理解DNA转座机制提供重要信息。
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