Vion-Dury J, Favre R, Sciaky M, Kriat M, Confort-Gouny S, Harlé J R, Grazziani N, Viout P, Grisoli F, Cozzone P J
Centre de Résonance Magnétique Biologique et Médicale, (URA CNRS 1186), Faculté de Médecine, Marseille, France.
NMR Biomed. 1993 Jan-Feb;6(1):58-65. doi: 10.1002/nbm.1940060110.
Proton high-resolution MRS of human plasma allows the rapid detection, on the same spectrum, of many compounds originating from different metabolic pathways. In this paper, we illustrate the modifications of the plasma metabolic profiles recorded by proton NMR spectroscopy in different classes of cancers. These modifications can be easily monitored with graphic aids such as 'star plots' which define for each type of cancer a particular pattern describing the most altered metabolic pathways. By using 'star plots' three types of metabolic patterns have been distinguished: (i) the 'inflammatory' pattern characterized by an increase of glycosylated moieties of glycoproteins; (ii) a 'lipid modified' pattern, characterized by various modifications occurring mainly in the lipid moieties detected by MRS; and (iii) a pattern which is often observed in sarcomas and mainly characterized by an alteration in the N-acetyl glucosamine/N-acetyl neuraminic acid ratio. This study demonstrates the ability of proton MRS of plasma to rapidly detect the occurrence of metabolic modifications brought about by cancer evolution or therapy.
人体血浆的质子高分辨率磁共振波谱能够在同一光谱上快速检测出源自不同代谢途径的多种化合物。在本文中，我们阐述了通过质子核磁共振波谱记录的不同类型癌症患者血浆代谢谱的变化。借助诸如“星状图”之类的图形辅助工具可以轻松监测这些变化，“星状图”为每种癌症类型定义了一种特定模式，描述了变化最大的代谢途径。通过使用“星状图”，区分出了三种代谢模式：（i）“炎症”模式，其特征是糖蛋白糖基化部分增加；（ii）“脂质改变”模式，其特征是主要在磁共振波谱检测到的脂质部分发生各种变化；（iii）一种常在肉瘤中观察到的模式，主要特征是N-乙酰葡糖胺/N-乙酰神经氨酸比值改变。这项研究证明了血浆质子磁共振波谱能够快速检测出癌症进展或治疗引起的代谢变化。
