血清反应阳性母亲所生婴儿体内针对水疱性口炎病毒（HTLV-I）假型的中和抗体
Neutralizing antibody to vesicular stomatitis virus (HTLV-I) pseudotype in infants born to seropositive mothers.
作者信息
Iwahara Y, Sawada T, Taguchi H, Hoshino H, Umemoto M, Take H, Foung S, Miyoshi I
机构信息
Department of Medicine, Kochi Medical School.
出版信息
Jpn J Cancer Res. 1993 Feb;84(2):114-6. doi: 10.1111/j.1349-7006.1993.tb02842.x.
Breast feeding is the major route of mother-to-child transmission of human T-cell leukemia virus type I (HTLV-I). Our experiments with rabbits have shown that passive immunization is capable of blocking cell-to-cell infection of HTLV-I by blood transfusion or breast feeding. In this study, sera were collected serially from 3 infants born to seropositive mothers and were tested for the presence of neutralizing antibody to vesicular stomatitis virus (HTLV-I) pseudotype as well as antibodies to viral structural proteins. There was a good correlation between neutralizing and viral antibody titers, both of which were detectable until 3-6 months after birth. Whether maternally transmitted neutralizing antibody is protective against perinatal infection of HTLV-I remains to be studied.
母乳喂养是人类T细胞白血病病毒I型（HTLV-I）母婴传播的主要途径。我们用兔子做的实验表明，被动免疫能够通过输血或母乳喂养阻断HTLV-I的细胞间感染。在本研究中，连续收集了3名血清反应阳性母亲所生婴儿的血清，检测其对水疱性口炎病毒（HTLV-I）假型的中和抗体以及病毒结构蛋白抗体的存在情况。中和抗体滴度与病毒抗体滴度之间存在良好的相关性，两者在出生后3至6个月均可检测到。母体传播的中和抗体是否能预防HTLV-I的围产期感染仍有待研究。
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