Tajima K, Tominaga S, Suchi T, Kawagoe T, Komoda H, Hinuma Y, Oda T, Fujita K
Gan. 1982 Dec;73(6):893-901.
About 20% of healthy inhabitants in the endemic area of adult T-cell leukemia/lymphoma (ATL) in Nagasaki Prefecture showed a positive antibody to adult T-cell leukemia virus (ATLV)-associated antigen (ATLA), while none of the inhabitants in a non-endemic area in Aichi Prefecture showed a positive anti-ATLA. The age-specific positive rate of anti-ATLA in the endemic area increased with age, especially in females. The positive rate of anti-ATLA among inhabitants older than 40 years was 21% in males and 36% in females. From epidemiological analyses of the mode of anti-ATLA reactivity among married couples and some family members and relatives with positive and negative anti-ATLA, two routes of transmission of ATLV were suggested. One route is from parents to children, either vertically or horizontally, and the other route is horizontal transmission between spouses, especially from husband to wife. The presence of some vectors of ATLV in the endemic area of ATL is discussed.
长崎县成人T细胞白血病/淋巴瘤（ATL）流行地区约20%的健康居民对成人T细胞白血病病毒（ATLV）相关抗原（ATLA）抗体呈阳性，而爱知县非流行地区的居民中无一例抗ATLA呈阳性。流行地区抗ATLA的年龄特异性阳性率随年龄增长而升高，尤其是女性。40岁以上居民中，男性抗ATLA阳性率为21%，女性为36%。通过对夫妻以及一些抗ATLA阳性和阴性的家庭成员及亲属中抗ATLA反应模式的流行病学分析，提示了ATLV的两种传播途径。一种途径是从父母垂直或水平传播给子女，另一种途径是配偶之间的水平传播，尤其是从丈夫传给妻子。文中还讨论了ATL流行地区存在一些ATLV传播媒介的情况。
