Suzuki S, Takahashi T, Nakamura S, Koike K, Ariyoshi Y, Takahashi T, Ueda R
Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya.
Jpn J Cancer Res. 1993 Feb;84(2):168-74. doi: 10.1111/j.1349-7006.1993.tb02851.x.
Integrins are cell-surface receptors which are involved in cell-matrix and/or cell-cell adhesion. They have been suggested to play a role in tumor invasion and metastasis. We examined the expression of various integrin subunits in normal and cancer cells of the lung using 33 human lung cancer cell lines as well as 6 lung cancer samples from which tumor cell lines could be established. This study clearly demonstrated that changes in the expression of certain integrins occur frequently in lung cancer, especially in small cell lung cancer. Loss of the alpha 1 subunit of the beta 1 integrin family appears to be the most prominent change, although loss of other integrin subunits such as alpha 2 or emergence of some integrin subunits such as alpha v can also be observed. These results suggest that changes in integrin expression may contribute to the invasive and/or metastatic behavior of lung cancer.
整合素是参与细胞与基质和/或细胞与细胞黏附的细胞表面受体。它们被认为在肿瘤侵袭和转移中发挥作用。我们使用33个人类肺癌细胞系以及6个可建立肿瘤细胞系的肺癌样本，检测了正常和肺癌细胞中各种整合素亚基的表达。这项研究清楚地表明，某些整合素表达的变化在肺癌中频繁发生，尤其是在小细胞肺癌中。β1整合素家族的α1亚基缺失似乎是最显著的变化，不过也可观察到其他整合素亚基如α2的缺失或某些整合素亚基如αv的出现。这些结果表明，整合素表达的变化可能有助于肺癌的侵袭和/或转移行为。
