新加坡甲型肝炎血清流行病学：变化趋势

Hepatitis A sero-epidemiology in Singapore: a changing pattern.

作者信息

Yap I, Guan R

机构信息

Department of Medicine, National University Hospital, Singapore.

出版信息

Trans R Soc Trop Med Hyg. 1993 Jan-Feb;87(1):22-3. doi: 10.1016/0035-9203(93)90405-f.

DOI:10.1016/0035-9203(93)90405-f

PMID:8385369

Abstract

Sera from 896 healthy volunteers between 15 and 56 years old were tested in 1987-1991 for immunoglobulin G antibody against the hepatitis A virus (IgG anti-HAV). The overall seroprevalence rate of IgG anti-HAV was 27%: it increased from 0.9% in the 10-19 years age group to 48.1% in the 40-49 years age group and was 100% in subjects over 50 years. There was no difference in anti-HAV seroprevalence between the sexes (29% among men and 26% among women) and races. A downward trend in anti-HAV seroprevalence was seen from 1987 (33%) to 1991 (21.4%). The level of exposure to the hepatitis A virus has decreased when compared with data obtained in 1975 and 1984-1985. Hepatitis A virus infection is no longer an infection of children and adolescents locally.

摘要

1987年至1991年期间，对896名年龄在15至56岁之间的健康志愿者的血清进行了甲型肝炎病毒免疫球蛋白G抗体（IgG抗-HAV）检测。IgG抗-HAV的总体血清阳性率为27%：从10至19岁年龄组的0.9%升至40至49岁年龄组的48.1%，50岁以上人群中则为100%。男女之间（男性为29%，女性为26%）以及不同种族之间的抗-HAV血清阳性率没有差异。1987年（33%）至1991年（21.4%）期间，抗-HAV血清阳性率呈下降趋势。与1975年以及1984年至1985年获得的数据相比，甲型肝炎病毒的暴露水平有所下降。在当地，甲型肝炎病毒感染已不再是儿童和青少年的专属感染。