Seiden M V, Sklar J
Division of Diagnostic Molecular Biology, Brigham and Women's Hospital, Boston, Massachusetts.
Hematol Oncol Clin North Am. 1993 Apr;7(2):447-65.
Lymphoproliferative disorders developing in the post-transplant setting are a devastating set of diseases with major implications for the patients who develop them. On the other hand, they have provided us with an opportunity to better understand the basic biology of these disorders and malignant lymphomas in general. Molecular gene rearrangement studies and the Epstein-Barr virus, which is found in the genome of most of the abnormal lymphocytes in these disorders, have been investigated to further our understanding of the development and progression of these diseases.
移植后发生的淋巴增殖性疾病是一组毁灭性的疾病，对罹患这些疾病的患者具有重大影响。另一方面，它们为我们提供了一个机会，使我们能够更好地总体了解这些疾病以及恶性淋巴瘤的基本生物学特性。已经开展了分子基因重排研究以及对爱泼斯坦-巴尔病毒（在这些疾病中大多数异常淋巴细胞的基因组中均可发现该病毒）的研究，以加深我们对这些疾病发生和发展过程的理解。
