Helm K F, Höpfl R M, Kreider J W, Lookingbill D P
Department of Medicine (Division of Dermatology), Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033.
J Cutan Pathol. 1993 Feb;20(1):84-6. doi: 10.1111/j.1600-0560.1993.tb01256.x.
The etiology of verruciform xanthoma, a rare lesion that usually occurs in the oral mucosa, is unknown. A viral etiology has been speculated since extraoral lesions usually occur in the genitalia. We present, to the best of our knowledge, the first reported case of verruciform xanthoma in an immunocompromised patient with chronic graft versus host disease. Immunohistochemical studies showed a few Ham 56 (a macrophage marker) positive foam cells, both in the dermis and within the epidermis, supporting a role for an epidermal process in production of the foam cells. Staining for human papillomavirus protein (HPV) showed reactivity of some of the nuclei in the dermal histiocytes, but in situ hybridization for HPV types 6/11, 16/18, and 31, 33 was negative. These results support an epidermal process as the stimulus for the foam cell formation but fail to demonstrate HPV as the cause.
疣状黄瘤是一种罕见的病变，通常发生于口腔黏膜，其病因尚不清楚。由于口外病变通常发生在生殖器部位，因此推测其病因与病毒有关。据我们所知，我们报告了首例慢性移植物抗宿主病免疫功能低下患者发生疣状黄瘤的病例。免疫组织化学研究显示，真皮层和表皮内均有少量Ham 56（巨噬细胞标志物）阳性泡沫细胞，支持表皮过程在泡沫细胞产生中起作用。人乳头瘤病毒蛋白（HPV）染色显示真皮组织细胞中的一些细胞核有反应，但HPV 6/11、16/18和31、33型的原位杂交为阴性。这些结果支持表皮过程是泡沫细胞形成的刺激因素，但未能证明HPV是病因。
