Harada S, Kishi T
J Antibiot (Tokyo). 1977 Jan;30(1):11-6. doi: 10.7164/antibiotics.30.11.
A new antibiotic amipurimycin, active against Pyricularia oryzae in vitro and in vivo, was isolated from the culture filtrate of Streptomyces novoguineensis nov. sp. The antibiotic was purified by a combination of ion-exchange and adsorption chromatography based on its amphoteric water-soluble characteristics. Its molecular formula was estimated to be C20H27approximately31N7O8-H2O. Characteristic maxima in the UV spectrum and signals in the PMR and CMR spectra were similar to those of 2-aminopurine 9-(beta-D)-riboside. These findings indicated that amipurimycin is a new nucleoside antibiotic and the first example of a natural product containing 2-aminopurine.
从新几内亚链霉菌新种的培养滤液中分离出一种新的抗生素氨嘌呤霉素，它在体外和体内对稻瘟病菌均有活性。基于其两性水溶性特征，通过离子交换和吸附色谱相结合的方法对该抗生素进行了纯化。其分子式估计为C20H27约31N7O8-H2O。紫外光谱中的特征最大值以及核磁共振氢谱和碳谱中的信号与2-氨基嘌呤9-(β-D)-核糖苷的相似。这些发现表明氨嘌呤霉素是一种新的核苷抗生素，也是含2-氨基嘌呤天然产物的首个实例。
