6'-C-氨甲基-3'-脱氧巴龙胺的合成
Syntheses of 6'-C-aminomethyl-3'-deoxyparomamines.
作者信息
Yamaguchi T, Tsuchiya T, Umezawa S
出版信息
J Antibiot (Tokyo). 1977 Jan;30(1):71-5. doi: 10.7164/antibiotics.30.71.
PMID:838633
Abstract
The first synthesis of 6'-C-aminomethyl derivatives (6'-epimers) of 3'-deoxyparomamine is reported starting from 3'-deoxyparomamine by way of 6'-O-tritylation, O-acetylation, hydrolysis of the trityl group, conversion of the 6'-hydroxyl group into an aldehyde group, nitromethane condensation of the aldehyde group and catalytic reduction of the nitro group into an amino group.
摘要
报道了从3'-脱氧巴龙胺出发，通过6'-O-三苯甲基化、O-乙酰化、三苯甲基基团水解、将6'-羟基转化为醛基、醛基与硝基甲烷缩合以及将硝基催化还原为氨基等步骤首次合成3'-脱氧巴龙胺的6'-C-氨甲基衍生物（6'-差向异构体）。
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