Yokoi M, Nagai T, Hirabayashi M, Okamura A, Tatsumi E, Nishikori M
Department of Internal Medicine, Hyogo Prefectural Tsukaguchi Hospital.
Rinsho Ketsueki. 1993 Mar;34(3):378-80.
A 57-year-old man was admitted with systemic lymphadenopathy. He had undergone resection for small cell lung carcinoma and received chemotherapy 6 years previously. A specimen of swollen lymph nodes showed malignant lymphoma. Surface marker analysis revealed the lymphoma to have the same characteristics as lymphoblastic lymphoma (LBL). He received combination chemotherapy, but marked resistance was recognized. His condition deteriorated rapidly and died. Having the characteristics of LBL on lymphoma at an older age and severe drug-resistance suggests that this lymphoma might have been a second malignancy due to preceding chemotherapy.
一名57岁男性因全身淋巴结肿大入院。他6年前曾因小细胞肺癌接受手术切除并接受化疗。肿大淋巴结的标本显示为恶性淋巴瘤。表面标志物分析显示该淋巴瘤具有与淋巴母细胞淋巴瘤(LBL)相同的特征。他接受了联合化疗,但出现明显耐药。他的病情迅速恶化并死亡。在老年患者中淋巴瘤具有LBL特征且存在严重耐药性提示该淋巴瘤可能是先前化疗所致的第二原发性恶性肿瘤。