Miller D L, Allen M S
Division of Thoracic and Cardiovascular Surgery, Mayo Clinic Rochester, Minnesota.
Mayo Clin Proc. 1993 May;68(5):492-8. doi: 10.1016/s0025-6196(12)60199-2.
We reviewed the clinical course and the results of various treatment modalities of 80 patients with rare pulmonary neoplasms, who constituted 0.8% of all patients with primary lung cancer treated at the Mayo Clinic from 1980 through 1990. The 50 male and 30 female patients had a median age of 60 years (range, 20 to 87). The histopathologic types of these rare pulmonary neoplasms were non-Hodgkin's lymphoma (41%), carcinosarcoma (20%), mucoepidermoid carcinoma (15%), malignant fibrous histiocytoma (5%), malignant melanoma (4%), fibrosarcoma (4%), leiomyosarcoma (4%), angiosarcoma (2%), hemangiopericytoma (2%), osteosarcoma (1%), and blastoma (1%). Follow-up was complete in all 80 patients, and the median duration of follow-up was 59 months (range, 15 to 130). Of the 80 patients, 63 (79%) underwent pulmonary resection. Of the other 17 patients, 8 underwent only bronchoscopy for diagnosis, 4 had unresectable disease at thoracotomy, 3 had metastatic disease on initial assessment, and 2 had mediastinal involvement detected on mediastinoscopy. Fifty-four patients (68%) received chemotherapy or radiation treatment (or both). The overall 5-year survival was 39%. The strongest factors that influenced survival were cell type and extent of disease at time of initial examination.
我们回顾了80例罕见肺肿瘤患者的临床病程及各种治疗方式的结果，这些患者占1980年至1990年在梅奥诊所接受治疗的所有原发性肺癌患者的0.8%。50例男性和30例女性患者的中位年龄为60岁（范围20至87岁）。这些罕见肺肿瘤的组织病理学类型包括非霍奇金淋巴瘤（41%）、癌肉瘤（20%）、黏液表皮样癌（15%）、恶性纤维组织细胞瘤（5%）、恶性黑色素瘤（4%）、纤维肉瘤（4%）、平滑肌肉瘤（4%）、血管肉瘤（2%）、血管外皮细胞瘤（2%）、骨肉瘤（1%）和成釉细胞瘤（1%）。所有80例患者均完成随访，中位随访时间为59个月（范围15至130个月）。80例患者中，63例（79%）接受了肺切除术。其他17例患者中，8例仅接受支气管镜检查以明确诊断，4例在开胸手术时发现无法切除的疾病，3例在初次评估时有转移性疾病，2例在纵隔镜检查时发现纵隔受累。54例患者（68%）接受了化疗或放疗（或两者）。总体5年生存率为39%。影响生存的最主要因素是初始检查时的细胞类型和疾病范围。
