大鼠双侧颈动脉闭塞期间一氧化氮生成的电子顺磁共振自旋捕获研究
EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat.
作者信息
Sato S, Tominaga T, Ohnishi T, Ohnishi S T
机构信息
Philadelphia Biomedical Research Institute, King of Prussia, PA 19406.
出版信息
Biochim Biophys Acta. 1993 Apr 30;1181(2):195-7. doi: 10.1016/0925-4439(93)90111-d.
PMID:8386941
Abstract
The formation of nitric oxide (NO) radicals was demonstrated by electron paramagnetic resonance spectroscopy in the rat during varying degrees of brain ischemia. Diethyldithiocarbamate and Fe-citrate were used as in vivo spin-trapping reagents. The signal of NO spin adducts increased in accordance with the degree of ischemic insults. The formation of NO radicals was inhibited by NG-nitro-L-arginine methyl ester.
摘要
通过电子顺磁共振光谱法在不同程度脑缺血的大鼠体内证实了一氧化氮（NO）自由基的形成。二乙基二硫代氨基甲酸盐和柠檬酸铁被用作体内自旋捕获试剂。NO自旋加合物的信号随着缺血损伤程度的增加而增强。NO自由基的形成受到NG-硝基-L-精氨酸甲酯的抑制。
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