Miller M L, Samuelson C O, Ward J R
Arthritis Rheum. 1978 Jul-Aug;21(6):681-9. doi: 10.1002/art.1780210612.
6-sulfanilamidoindazole (6-SAI), an antibacterial sulfonamide, is known to cause an acute, self-limited inflammatory reaction in the hind paws of older rats. Administration of 6-SAI results in hyperfibrinogenemia which precedes the onset of clinical arthritis. The hyperfibrinogenemia is associated with the prolongation of dilute blood clot lysis times, appearance of heparin-precipitable fibrinogen, elevations in fibrin degradation products, and complement titers and serum electrophoretic pattern changes that consist of decreased albumin concentrations and increased beta globulin concentrations. Alterations in 6-SAI medicated young rats are less marked and require higher doses.
6-磺胺氨基吲唑（6-SAI）是一种抗菌磺胺类药物，已知会在老年大鼠的后爪引发急性、自限性炎症反应。给予6-SAI会导致血纤维蛋白原血症，这发生在临床关节炎发作之前。血纤维蛋白原血症与稀释血液凝块溶解时间延长、肝素可沉淀纤维蛋白原的出现、纤维蛋白降解产物升高、补体滴度以及血清电泳图谱变化有关，血清电泳图谱变化包括白蛋白浓度降低和β球蛋白浓度升高。用6-SAI处理的幼鼠的变化不太明显，且需要更高剂量。
