Hirschelmann R, Schade R, Bekemeier H
Agents Actions. 1980 Nov;10(5):431-4. doi: 10.1007/BF01968042.
During 6-sulphanilamidoindazole (6-SAI) arthritis a significant increase of serum levels of the protease inhibitor alpha 2 macroglobulin (= alpha 2 acute phase globulin) and of Darcy's glycoprotein was found, whereas the content of female specific protein and of sulfhydryl groups was proved to be significantly decreased. Intravenous administration of 5 mg/kg soybean trypsin inhibitor, twice daily for 4 days, was without any inhibitory effect on paw swelling in 6-SAI arthritis but it caused increased serum levels of alpha 2 macroglobulin and Darcy's glycoprotein. Thus, spontaneous remission of 6-SAI arthritis occurring, despite continued administration of 6-SAI, seems hardly likely to be caused by acute-phase reactants, e.g. via protease inhibition. Evidence is presented which shows that spontaneous remission of 6-SAI arthritis could be due to local processes.
在6-磺胺氨基吲唑（6-SAI）性关节炎期间，发现蛋白酶抑制剂α2巨球蛋白（=α2急性期球蛋白）和达西糖蛋白的血清水平显著升高，而女性特异性蛋白和巯基的含量则被证明显著降低。每天两次静脉注射5mg/kg大豆胰蛋白酶抑制剂，持续4天，对6-SAI性关节炎的爪肿胀没有任何抑制作用，但它导致α2巨球蛋白和达西糖蛋白的血清水平升高。因此，尽管持续给予6-SAI，6-SAI性关节炎仍会自发缓解，这似乎不太可能是由急性期反应物引起的，例如通过蛋白酶抑制。有证据表明，6-SAI性关节炎的自发缓解可能是由于局部过程。
