Polihronis M, Paizis K, Carter G, Sedal L, Murphy B
Department of Nephrology, St. Vincent's Hospital, Melbourne, Australia.
J Neurol Sci. 1993 Apr;115(2):230-3. doi: 10.1016/0022-510x(93)90230-v.
Clusterin is a serum glycoprotein which is an inhibitor of complement and is expressed in many tissues in cell injury and death. It has been identified normal and pathological brain tissue and is a component of normal human cerebrospinal fluid (CSF). We have measured the clusterin concentration of 115 abnormal and normal human CSF samples and related these data to the patient's clinical diagnoses. CSF clusterin levels in patients with neurodegenerative and meningeal disease were within the normal range. Twelve of 15 patients with demyelination, however, had significant elevation of CSF clusterin concentration. This was not a specific finding for multiple sclerosis as elevated clusterin levels were also seen in patients with other acute neuropathology. Determination of CSF clusterin concentration may be of clinical value in neurological diagnosis.
聚集素是一种血清糖蛋白，它是补体的抑制剂，在细胞损伤和死亡时在许多组织中表达。它已在正常和病理脑组织中被鉴定出来，并且是正常人脑脊液（CSF）的一个组成部分。我们测量了115份异常和正常人类脑脊液样本中的聚集素浓度，并将这些数据与患者的临床诊断相关联。神经退行性疾病和脑膜疾病患者的脑脊液聚集素水平在正常范围内。然而，15例脱髓鞘患者中有12例脑脊液聚集素浓度显著升高。这并非多发性硬化症的特异性表现，因为在其他急性神经病理学患者中也观察到聚集素水平升高。测定脑脊液聚集素浓度在神经学诊断中可能具有临床价值。
